Looking for the best wager among all 16 NFL matchups in Week 15? Our selection, in terms of the point spreads, is Vikings -7. But see below, because we have lots more tips, and that could lead to parlay possibilities.

Take advantage of our predictions to make your NFL picks this week. BetMGM has all the information you need to begin betting on the NFL.

Best Week 15 Spread Bets

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DAL-CAR | BUF-DET | LAR-SF | MIA-HOU | TB-LAC

Pick: Cowboys +2.5 vs. Panthers

• Matchup: Dallas Cowboys at Carolina Panthers
• Projected Winner & Margin: Cowboys by 1.7 points (Bet on this game at BetMGM)
• Spread: Panthers -2.5
• Time: 1 p.m. ET
• Date: Dec. 15
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Lions -2.5 vs. Bills

• Matchup: Buffalo Bills at Detroit Lions
• Projected Winner & Margin: Lions by 8.6 points (Bet on this game at BetMGM)
• Spread: Lions -2.5
• Time: 4:25 p.m. ET
• Date: Dec. 15
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Rams +3 vs. 49ers

• Matchup: Los Angeles Rams at San Francisco 49ers
• Projected Winner & Margin: 49ers by 1.8 points (Bet on this game at BetMGM)
• Spread: 49ers -3
• Time: 8:15 p.m. ET
• Date: Dec. 12
• TV Channel: Amazon Prime Video
• Live Stream: Watch this game on Prime Video (Regional restrictions may apply)

Pick: Texans -3 vs. Dolphins

• Matchup: Miami Dolphins at Houston Texans
• Projected Winner & Margin: Texans by 10.5 points (Bet on this game at BetMGM)
• Spread: Texans -3
• Time: 1 p.m. ET
• Date: Dec. 15
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Buccaneers +3 vs. Chargers

• Matchup: Tampa Bay Buccaneers at Los Angeles Chargers
• Projected Winner & Margin: Chargers by 0.7 points (Bet on this game at BetMGM)
• Spread: Chargers -3
• Time: 4:25 p.m. ET
• Date: Dec. 15
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Make smart decisions. Use those stats when making your NFL picks and place your bet on BetMGM.

Best Week 15 Total Bets

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Under 54.5 – Bills vs. Lions

• Matchup: Buffalo Bills at Detroit Lions
• Projected Total: 50.6 points (Bet on this game at BetMGM)
• Time: 4:25 p.m. ET
• Date: Dec. 15
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Over 42.5 – Steelers vs. Eagles

• Matchup: Pittsburgh Steelers at Philadelphia Eagles
• Projected Total: 43.7 points (Bet on this game at BetMGM)
• Time: 4:25 p.m. ET
• Date: Dec. 15
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Over 46 – Packers vs. Seahawks

• Matchup: Green Bay Packers at Seattle Seahawks
• Projected Total: 46.5 points (Bet on this game at BetMGM)
• Time: 8:20 p.m. ET
• Date: Dec. 15
• TV Channel: NBC
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Under 45.5 – Buccaneers vs. Chargers

• Matchup: Tampa Bay Buccaneers at Los Angeles Chargers
• Projected Total: 44.5 points (Bet on this game at BetMGM)
• Time: 4:25 p.m. ET
• Date: Dec. 15
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Under 43.5 – Bears vs. Vikings

• Matchup: Chicago Bears at Minnesota Vikings
• Projected Total: 42.7 points (Bet on this game at BetMGM)
• Time: 8 p.m. ET
• Date: Dec. 16
• TV Channel: ABC
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

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